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Generate density, probability, quantile and random generation functions for (scaled) empirical mortality distribution

Source: R/generate_mortality_funs.R
generate_mortality_funs.Rd

The cumulative mortality functions is modelled over that of the CLASSIC trial (see details), but can be scaled to achieve a desired mortality at end of follow-up

Usage

generate_mortality_funs(cum_mortality = NULL, censoring_value = NA)

Arguments

cum_mortality

scalar in [0, 1], the cumulative mortality at end of follow-up (= time of censoring)

censoring_value

the value assigned when a patient is censored, default is NA

Value

A list with the four functions, named d, p, q and r to follow R conventions (see, e.g., ?rnorm)

Details

The built-in cumulative mortality function is based on results from the standard arm in the Conservative versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) trial (see references below).

References

Meyhoff TS et al. (2022). Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med (https://doi.org/10.1056/NEJMoa2202707).

Kjaer M-BN et al. (2023). Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock. Intensive Care Med (https://doi.org/10.1007/s00134-023-07114-8)